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On the nucleophile side, reduced thiols are critical, as they attack the o -quinone intermediate formed by tyrosinase

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The introduction of Gly 8 circumvented the DPP-IV degradation and led to a longer half-life, as a single injection of 0.1 nmol of the peptide to diabetic mice normalized fasting hyperglycemia and glucose intolerance for several hours, whereas the activity of 1 nmol of the native GLP-1 vanished in a few minutes

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Additionally, when GLP-1 is administered peripherally, it can affect the central regulation of feeding, impacting our brains perception of hunger and fullness

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Impact of allogeneic dental pulp stem cell injection on tissue regeneration in periodontitis: a multicenter randomized clinical trial

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